bears the signature of two new medical discovery by Italian researchers published this week in the journal Nature : Dr Stefania Gonfloni and Prof. Gianni Cesareni University of Rome Tor Vergata have identified a way to protect the fertility of women undergoing chemotherapy.
Radio and chemotherapy - the most common treatments to fight cancer - make use of physical or chemical agents that cause DNA lesions and the subsequent death or "suicide" of damaged cells. I'm so aggressive treatments that can affect not only cancer cells but also those of healthy organs causing side effects. And in the case of women, the loss of fertility is certainly the side effect of permanent and one that has the greatest impact on their quality of life, despite failing to heal cancer.
The new study researchers from the Department of Biology, Tor Vergata is in having found a technique to prevent the suicide of damaged egg cell.
fertility in women depends on the number of egg cells "eggs" found in the ovary at birth, cells are very sensitive to injury or DNA breaks, which is why they are particularly affected during the chemotherapy treatments.
The researchers have now identified the gene c-Abl gene "modifier" gene "sentinel" TAp63. When injuries occur in the DNA, these genes in turn trigger the activation of the protein product of the gene c-Abl in response to changes TAp63 protein rapidly from "sentinel" on powerful "suicide bomber" capable of bringing the cell "egg" to suicide. In the laboratories of Roman
Biology have now shown that treatment during chemotherapy, the use of the inhibitor of c-Abl allowed to protect the oocyte cell death and thus prolong the fertility in mice, which have generated a apparently normal offspring.
So far, the only option for young women at risk of losing their fertility after cancer treatment is made by freezing the oocytes can then be used for in vitro fertilization. However, a methodology that can not be appropriate for some patients for reasons of age, or type of cancer.
The discovery of Roman researchers opens the way for an alternative that casts a hope for girls and women who are forced to deal with chemotherapy. The next step will now test the protective effect of the inhibitor of c-Abl from mice to humans.
study, a collaboration of research groups and the Department of Biology, Faculty of Medicine of the University of Rome "Tor Vergata", was funded by the ' AIRC (Italian Association for Cancer Research) .
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