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cannabis could contribute to male infertility

CNR: cannabis could contribute to male infertility

Substance abuse cannabis, the main constituent of marijuana, may help to cause infertility 'man. This was confirmed by the study 'The endocannabinoid system and the pivotal role of the CB2 receptor in mouse spermatogenesis', opening new perspectives for understanding the phenomena of oligospermia or azoospermia (total absence or drastic reduction in the number of sperm, often with reduction of motility' ), particularly in those patients with normal chromosome and the absence of known genetic defects or occlusive disease.
The research, published in the journal PNAS, Proceedings of the National Academy of Sciences, and 'was conducted in collaboration between researchers at the National Research Council - Institute of Biomolecular Chemistry (ICB-CNR), Institute of Cybernetics (IC-CNR) and Institute of Biochemistry of protein (IBP-CNR) - and of Universita 'di Roma Tor Vergata. It demonstrates for the first time that, in mice, the endocannabinoid system (ie 'the system on which also acts as marijuana) is involved in the process of spermatogenesis.

'In recent years,' says Pierangelo Orlando dell'Ibp-CNR, 'we have seen a progressive increase in the incidence of infertility' as a couple. According to the most 'recent statistics in the world, would be about 15% of couples with problems of failure or reduced fertility ', and 40% attributable to oligospermia or azoospermia men.
Potential causes of impaired fertility 'men are due to 60% of the cases to a genetic origin and the remaining 40% occlusive malformations or which are beyond the classification'.
dell'oligospermia One of the reasons, among those who currently are not falling - continues the researcher and member of the Endocannabinoid Research Group coordinated by Vincenzo Di Marzo ICB-CNR - could be attributed to poor functioning of the endocannabinoid system, which also 'abuse of cannabis can' interfere. 'It has been observed that germ cells in the testis have receptors in the endocannabinoid system of the animal and, in particular, that the cannabinoid receptor type 2 (CB2) and 'involved in the meiotic process by which any primary spermatocyte (which in the male of the species presents human chromosome 46, XY) gives 4 new cells (spermatids) 2 with chromosome 23, X and 2 set-23, Y, which give rise to mature sperm during spermiogenesis. Parallel pharmacological studies demonstrate the ability 'to modulate the endocannabinoid system in vivo by CB2 receptor agonists and antagonists and inhibitors of the formation or degradation of endocannabinoids, thus opening' the way for therapeutic approaches in case of malfunction '.
Finally, the researcher concludes, 'the use of medically assisted fertilization (ICSI-intro-cytoplasmic sperm injection in the egg, possibly after aspiration of residual sperm from the testis-TESA), if it has resolved most of the cases of infertility' male , resulted in a statistically significant increase in the offspring of both genetic transmission of infertility ', is an effect from 6 to 9 times more chromosomal abnormalities, in particular those defined' by a lack of imprinting '(overdosing genetic) syndromes such as Beckwith-Wiedemann, Angelman, Prader-Willi syndrome ', rare genetic diseases characterized by major changes in anatomical and functional increased risk of cancer.

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